Conan O'Brien: The Kennedy Center Mark Twain Prize for American Humor80Conan O'Brien: The Kennedy Center Mark Twain Prize for American Humor80thumb_upthumb_downConan O'Brien: The Kennedy Center Mark Twain Prize for American HumorComedy stars unite to honor Conan O'Brien as he receives the Mark Twain Prize for American Humor.US content warning Last Updated: December 31, 2025 Request Update CastConan O'BrienSelf - Honoree