Test pilot Tuck Pendleton volunteers to test a special vessel for a miniaturization experiment. Accidentally injected into a neurotic hypochondriac, Jack Putter, Tuck must convince Jack to find his ex-girlfriend, Lydia Maxwell, to help him extract Tuck and his ship and re-enlarge them before his oxygen runs out.
Practical Effects
Gross, gooey body interior sets that still look tactile and weird.
Acting
Martin Short's full-body panic as his own nervous system betrays him.
Direction
Joe Dante's cartoon physics applied to human biology.
Director
Joe Dante
Dennis Quaid
Lt. Tuck Pendleton
Martin Short
Jack Putter
Meg Ryan
Lydia Maxwell
Kevin McCarthy
Victor Eugene Scrimshaw
Fiona Lewis
Dr. Margaret Canker
Vernon Wells
Mr. Igoe
Robert Picardo
The Cowboy
Wendy Schaal
Wendy
Harold Sylvester
Pete Blanchard
William Schallert
Dr. Greenbush
Henry Gibson
Mr. Wormwood
John Hora
Ozzie Wexler
Mark L. Taylor
Dr. Niles
Orson Bean
Lydia's Editor
Kevin Hooks
Duane
Trivia, insights & behind the scenes
This was originally developed as a straight sci-fi thriller until Spielberg suggested Dante and comedy; the original script was much darker.
The 'inside the body' sequence directly inspired Osmosis Jones and countless pharmaceutical commercials; Dante later said it was his 'most expensive cartoon.'
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